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CHICAGO Cheap Ivan Perisic Jersey , Nov. 7 (Xinhua) -- A study led by the University of Michigan (UM) found that increasing the levels of the fat hormone Neuregulin 4 (Nrg4) protected liver cells from metabolic stress in mice, while loss of the hormone had the opposite effect: mouse livers deteriorated and progressed to nonalcoholic steatohepatitis (NASH) more quickly.
UM cell biologist Jiandie Lin and his colleagues evaluated the effects of Nrg4 in mice that had been fed the type of high-fat, high-sugar diet that leads to fatty liver disease.
The findings have been published in the latest issue of the Journal of Clinical Investigation.
They found that when the hormone was elevated, less cell death, less inflammation, less fibrosis were detected.
On the other hand Cheap Geoffrey Kondogbia Jersey , mice lacking the hormone fare much worse. The hormone is having a distinct function that limits cell death and prevents progression to the most severe fatty liver disease.
More than a third of U.S. adults and up to 10 percent of children have some form of fatty liver disease. In up to 20 percent of these patients, the liver cells begin dying, and the disease develops into NASH.
It is estimated that by 2020, NASH will become the leading cause of the need for liver transplants, surpassing hepatitis and alcoholic liver disease.
The findings are an expansion of a previous study from Lin's lab, which showed Nrg4 could prevent the liver from converting sugar into fat Cheap Gary Medel Jersey , lowering the risk of fatty liver disease at its outset.
Moreover, the researchers have not yet seen any negative side-effects in the mice with increased Nrg4.
Based on the findings, researchers believe that Nrg4 may be an effective target for therapeutic intervention of NASH.
Lin's lab is now focusing on further testing the therapeutic viability of the hormone in treating NASH.
fire erupted on a school bus after it backed into a ditch in western Iowa early Tuesday, killing a student and the bus driver, investigators said.
No one else was on the bus when the fire erupted around 7 a.m. southeast of Oakland, which is about 35 miles (56 kilometers) east of Omaha Cheap Gabriel Jersey , Nebraska.
Investigators said the bus caught fire after it backed out of a farm driveway and into a ditch across the road. The bus was engulfed in flames when firefighters arrived.
The remains of the driver and a student were found after the fire was extinguished, Pottawattamie County Sheriff's Lt. Rob Ambrose said. The cause of the fire remains under investigation.
Initial reports on the fire indicated that as many as 20 people may have been on the bus, but Ambrose said only the student and the driver who were killed were in the bus at the time of the fire.
Authorities identified the driver as Donnie Hendricks, 74, of Carson, Iowa. The student was identified as Megan Klindt Cheap Eder Jersey , 16. She lived at the farm where the fire happened.
The bus was from the Riverside Community School District, which has about 700 students from Oakland and two other nearby towns. District officials said grief counselors were available Tuesday to help students and staff cope with the deaths.
"This morning, the Riverside Community School District suffered a tragedy when we lost a student and an employee in a school bus accident," Superintendent Timothy Mitchell said in a statement. "Our hearts go out to their families and loved ones."
The district didn't cancel classes following news of the fire, but it postponed all after-school activities scheduled for Tuesday.
Bailey Rose, 18 Cheap Davide Santon Jersey , told the Omaha World-Herald she took a weightlifting class with Klindt last year and remembers her caring and energetic nature.
"I know it's even harder for family members to deal with that kind of loss," Rose said. "Friends are dealing with it hard, but family is dealing with it harder."
Agencies
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